TIREDNESS & FATIGUE
CHECK PLUS BLOOD TEST
An advanced test to investigate why you might be feeling so tired. This test profile is a detailed examination of the main causes of fatigue.
Tiredness and Fatigue Check Plus Blood Test
About this test – Why take this test?
- You are abnormally tired and want a detailed investigation into the reasons why
- You want to get your energy back so that you can live your life normally
- You have more aches and pains than usual
Feeling tired all the time is one of the most common reasons why people visit their doctor, but sometimes finding out the reasons for your symptoms can be a journey of trial and error. This advanced fatigue profile aims to get to the cause of low energy levels by looking at many of the common causes of fatigue. Often fatigue is caused by anaemia, either from iron deficiency or because of low levels of vitamin B12 which is essential for the creation of normal red blood cells.
This profile checks your iron status, active vitamin B12 and folate levels and also takes a detailed look at your red blood cells to make sure that they show no signs of anaemia. We also look at your white blood cells to check that infection or inflammation is not contributing to your symptoms, as well as vitamin D deficiency, a very common cause of low energy and aches and pains. Finally, we look at your diabetes risk and thyroid function to make sure that an underactive thyroid is not behind your symptoms.
This advanced tiredness and fatigue profile was designed by our medical director and GP, Dr Sam Rodgers and is recommended for anyone who wants to get to the bottom of why they are feeling tired all the time.
How it Works:
Order your test. We will arrange for one of our trained phlebotomists to take your sample and send it to our accredited laboratory.
We will email you with your results within the specified turnaround times.
Our tests are not a substitute for seeing your doctor, especially if you are suffering symptoms. We can arrange to have your results interpreted based on the information you have provided, but will not diagnose, consult or provide any treatment. (This incurs an additional cost and will need to be requested at time of ordering).
You will be advised to see your doctor.
The prices shown above do not include Phlebotomy fees.
Red Blood Cells
Haemoglobin carries oxygen and gives the red blood cell its red colour. This test measures the amount of haemoglobin in the blood and is a good measure of the blood’s ability to carry oxygen around the body.
A high haemoglobin result can mean increased red cell production to compensate for chronically low oxygen levels in the blood caused by lung disease or living at altitude. While it can also indicate “blood doping” other causes can include dehydration, smoking and bone marrow disorders.
A low haemoglobin result indicates anaemia which can have many causes including pregnancy, blood loss, liver damage, iron deficiency and much more. A low haemoglobin level should be investigated in line with other symptoms and results.
HCT (haematocrit) measures the amount of space (volume) red blood cells take up in the blood.
Raised levels can result from pregnancy, living at altitude, dehydration as well as low availability of oxygen through chronic lung disease and even sleep apnoea.
Low levels indicate anaemia.
Red blood cell (RBC) count analyses the number of red cells in the blood. Red blood cells carry oxygen from the lungs to the rest of the body. They also carry carbon dioxide back to the lungs so that it can be exhaled.
A high count (thicker blood) means there is a chance that the red blood cells will clump together and block tiny blood vessels. This also makes it difficult for your red blood cells to carry oxygen.
A low count (anaemia) means that your body may not be getting the oxygen it needs and can be caused by nutritional deficiency (lack of iron, folic acid, vitamin B12), over-hydration as well as bleeding and bone marrow disorders.
MCV (mean corpuscular volume) reflects the size of your red blood cells.
A high result may indicate a vitamin deficiency of folate or vitamin B12 and is often seen in excessive alcohol consumption associated with liver inflammation.
A low result indicates anaemia, often caused by iron deficiency.
MCH (mean corpuscular haemoglobin) is the average amount of haemoglobin contained in your red blood cells.
Together with MCV and MCHC, MCH results can help in the diagnosis of different types of anaemia.
MCHC (mean corpuscular haemoglobin concentration) is the average concentration of haemoglobin in your red blood cells.
A high level can indicate the presence of spherocytes (a type of red bood cell with too much haemoglobin) or a deficiency of folic acid or vitamin B12 in the diet.
A low level can indicate chronic blood loss or iron deficiency.
RDW (red cell distribution width) shows whether the cells are all the same size or different sizes or shapes. Normally cells are fairly uniform, although a raised RDW result (indicating greater variation in cell size and shape than is normally seen) can be caused by deficiency in iron, vitamin B12 or folic acid.
White Blood Cells
White blood cells are key to your body’s immune or defence system. They fight infections and protect your body from foreign invaders such as harmful germs and bacteria.
A raised white blood cell (WBC) count can indicate recent infection, inflammation, trauma and even stress. Your WBC can also be raised when taking certain medications.
A decreased WBC can result from a vitamin deficiency such as folate or vitamin B12, as well as liver disease and diseases of the immune system.
Neutrophils are a type of white blood cell that are responsible for helping your body fight infection. When neutrophils are low you can be more vulnerable to illness and infection.
Neutrophils can be raised after severe stress on the body from a bacterial infection, recent exercise or sudden kidney failure.
Low neutrophils can be caused by a deficiency in vitamin B12 or folic acid, severe bacterial infection and some autoimmune diseases.
Lymphocytes are a type of white blood cell which fight bacterial and viral infections. They include T cells, B cells and natural killer cells.
Lymphocytes can be elevated for many reasons but it is common for them to be raised after recent infection, particularly after the flu. They can also be raised due to autoimmune disorders and some cancers.
The most common cause for lymphocytes to be depleted is the common cold.
Monocytes are a type of white blood cell that engulf and remove pathogens and dead or damaged cells from our blood. The heat and swelling of inflammation is caused by the activities of these cells.
Elevated monocytes can indicate chronic inflammatory disease, chronic infection, parasitic infection and Cushings disease.
Low levels can be due to autoimmune disorders such as lupus and rheumatoid arthritis as well as drugs which affect the bone marrow such as those used in chemotherapy.
Eosinophils are a type of white blood cell whose function is to remove parasitic infections as well as to regulate inflammation to mark an infected site.
Levels of eosinophils can be elevated if the scale of inflammation is greater than necessary to control the damage (as is the case in asthma and allergic responses) as well as in parasitic and fungal infections, autoimmune diseases and skin disorders.
Low levels of eosinophils are not usually cause for concern and can be caused by the administration of steroids.
Basophils are a type of white blood cell that protect your body from bacteria and parasites such as ticks.
An elevated basophil count can be due to inflammatory conditions such as Crohn’s disease, ulcerative colitis and dermatitis, recent infection and hormone imbalance (e.g. hypothyroidism).
A low basophil count can be caused by pregnancy, stress and use of steroids.
Platelets or clotting cells are the smallest type of blood cell and are important in blood clotting. When bleeding occurs, the platelets swell, clump together and form a sticky plug (a clot) which helps stop the bleeding.
If platelet levels are raised there is an increased risk of blood clots forming in blood vessels.
If platelet levels are too low there is a risk of easy bruising and uncontrolled bleeding.
MPV (mean platelet volume) is a measurement of the average size of your platelets. New platelets are larger than older ones and a raised MPV result occurs when increased numbers of platelets are being produced. MPV provides an indication of platelet production in your bone marrow.
HbA1c or Haemoglobin A1c is also known as glycosylated haemoglobin and is a longer term measure of glucose levels in your blood than a simple blood glucose test. Glucose attaches itself to the haemoglobin in your red blood cells, and as your cells live for around 8-12 weeks it provides a good indication of the level of sugar in your blood over a 2-3 month period.
This is an important measure for diagnosing type 2 diabetes as well as understanding how well blood sugar levels are being controlled in people who have already been diagnosed with diabetes.
C-Reactive Protein (CRP) is an inflammation marker used to assess whether there is inflammation in the body – it does not identify where the inflammation is located. High Sensitivity CRP (CRP-hs) is a test which is used to detect low-level inflammation which is thought to damage blood vessels which can lead to a heart attack or stroke.
Raised levels are a risk factor for cardio-vascular disease.
This test measures how much iron is in your blood with the aim of identifying iron deficiency anaemia or iron overload syndrome (haemochromatosis)
The symptoms of too much or too little iron can be similar – fatigue, muscle weakness, moodiness and difficulty concentrating.
A raised result can mean that you have iron overload syndrome, an inherited condition where your body stores too much iron, or that you are over-supplementing or that you have a liver condition.
A low result can mean that you are anaemic or are suffering from gastro-intestinal blood loss (or other blood loss). Anaemia is also very common in pregnant women.
Total iron binding capacity (TIBC) is a measure of the amount of iron that can be carried through the blood.
A raised TIBC result usually indicates iron deficiency whereas low TIBC can occur with iron overload syndrome (haemochromatosis).
Transferrin is made in the liver and is the major protein in the blood which binds to iron and transports it through the body.
Low transferrin saturation levels can indicate iron deficiency while high levels can indicate iron overload.
Ferritin is a protein which stores iron in your cells for your body to use later. Measuring ferritin levels gives us a good indication of the amount of iron stored in your body.
Low levels of ferritin can indicate anaemia which can be caused by excessive or chronic bleeding, poor absorption of iron or too little iron in the diet.
Raised ferritin levels can indicate iron overload syndrome (haemochromatosis) or any kind of liver damage. It is also a marker of infection and inflammation.
Thyroid Stimulating Hormone (TSH) is produced in the pituitary gland and stimulates the thyroid gland to produce thyroid hormones thyroxine (T4) and triiodothyronine (T3).
High levels of TSH indicate an underactive thyroid while low levels indicate an overactive thyroid. In primary pituitary failure, a low TSH will be associated with an underactive thyroid.
Thyroxine (T4) is one of two hormones produced by the thyroid gland. Most T4 is bound to carrier proteins in the blood. This test measures the level of T4 which is free, or unbound, circulating in your blood.
High levels of free thyroxine can indicate an overactive thyroid while low levels can indicate an underactive thyroid.
Vitamin B12 is important for production of red blood cells which carry oxygen around the body – low levels can cause anaemia with associated symptoms of lack of energy and fatigue. It is also important in metabolism and for the nervous system and prolonged lack of vitamin B12 may cause nerve damage. Vitamin B12 is almost entirely found in meat and animal food products.
Around 70% of vitamin B12 is bound to carrier proteins in your blood. This test measures the level of unbound or active B12 which is available for your cells.
A common reason for elevated B12 is over-supplementation. Raised levels of vitamin B12 may indicate a blood or liver disorder.
Low levels are seen in people with pernicious anaemia, an autoimmune disease which prevents the absorption of vitamin B12, or anyone who suffers from absorption problems such as the elderly, people with inflammatory bowel conditions and alcoholics. Vegetarians and vegans can also be low in vitamin B12, especially if they don’t consume foods which have been fortified with vitamin B12 or take B12 supplements.
Folate is a water soluble vitamin which is needed by the body in your diet every day. It plays a role in DNA replication and protection, it’s important for the production of red blood cells as well as in the prevention of neural tube defects in babies.
Low levels can indicate anaemia and can be implicated in raised homocysteine levels.
Although called a vitamin, vitamin D is actually a hormone which is activated by sunshine on your skin. Vitamin D is essential for bone strength as it helps your intestines absorb calcium. However, it is thought that vitamin D also plays an important role in immune function, as well as in many chronic diseases and mental health.
Many people in the UK do not produce enough Vitamin D, especially in the winter months with fewer daylight hours. It is now recommended that you get 10 – 15 minutes of unprotected sun exposure every day to ensure you are producing enough vitamin D. In winter months, if your levels are found to be low, you may wish to take a supplement.
If you would like to make an enquiry or arrange a blood test can you please fill in the contact form below or call us on 01633 718001